Generic Copegus (Ribavirin)
Copegus is used to treat chronic hepatitis C which is a disease of the liver. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body.
Per Pills
100 mg x 30 pills
100 mg x 60 pills
100 mg x 90 pills
Product Description

Copegus - have

Thyroid disorders: This medication can cause or worsen hypothyroidism low thyroid or hyperthyroidism high thyroid. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Side effects Medicines and Copegus possible side effects can affect individual people in different ways. Before you take Copegus, tell your healthcare provider if you have or have had:. Declining lung cancer mortality helped fuel the progress. Department of Health and Human Services. An interaction between two medications does not always mean that you must stop taking one of them. Talk to your healthcare provider before starting treatment with Copegus if you have any of these medical conditions. Respiratory, Thoracic and Mediastinal. What will it do for me. Generic Name: ribavirin Dosage Form: tablet, film coated. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. If possible, avoid contact with people with contagious infections. Photo: Andrew Karpenko, University of Washington. A Ribavirin Pregnancy Registry has been established to monitor maternal-fetal outcomes of pregnancies of female patients and female partners of male patients exposed to ribavirin during treatment and for 6 months following cessation of treatment. Patients in whom efficacy was demonstrated included patients with compensated liver disease and histological evidence of cirrhosis Child-Pugh class A. Pre-existing cardiac disease: do ECG prior to therapy and monitor. This medication is available as a package containing ribavirin tablets and peginterferon alfa-2a injections. All patients received 48 weeks of therapy followed by 24 weeks of treatment-free follow-up. FDA alerts for all medications. This article is being kept available Copegjs Copegus purposes only. All 14 patients were on NRTIs, including stavudine, didanosine, abacavir, zidovudine, and lamivudine. Do not freeze, shake, or use them past the expiry date. Skip to Content. Genotype non-1 predominantly 2 and 3 patients who were treated with the 24 week lower Copegus dose regimen experienced fewer side effects. A dominant lethal assay in rats was negative, indicating that if mutations occurred in rats they were not transmitted through male gametes.

Copegus - much

Genotype non-1 predominantly Copegus and 3 patients who were treated with the 24 week lower Copegus dose regimen experienced fewer side effects. Rochebased in Nutley, N. In both studies, virus genotype was clearly the strongest predictor of whether or not a patient achieved a sustained virological response. The hemolytic anemia can occur suddenly and can result in worsening of cardiac disease, even leading to myocardial infarction. The missed doses should be taken as soon as possible during the same day. You should discuss this with your doctor before starting treatment. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Study finds fewer than half of trials followed the law. Thirty-eight of the subjects enrolled in the long-term follow-up study, extending up to 6 years post-treatment. The entrance criteria used for the clinical studies of Copegus and PEGASYS may be considered as a guideline to acceptable baseline values for initiation of treatment:. The Copegus brand name has been discontinued in the U. The most common adverse event associated with ribavirin is anemia, which may be severe [see Boxed WarningWarnings and Precautions 5. Loss of appetite, weight loss. Drug Summary Ribavirin has been an integral component of hepatitis C therapy. No clinically significant differences in the pharmacokinetics of ribavirin were observed between male and female subjects. If you experience signs of a severe allergic reaction such as difficulty in breathing, wheezing, swelling of the face, tongue or throat, or hives while on this medication, seek medical help immediately. Gastrointestinal disorders. Musculoskeletal, connective tissue and bone disorders. In rats, retinal degeneration occurred in controls, but the incidence was increased in ribavirin-treated rats. Ribavirin demonstrated mutagenic activity in the in vitro mouse lymphoma assay. This combination medication is used to treat certain forms of chronic hepatitis Cwhich is a disease of the liver. Men taking this medicine must use condoms to avoid fathering a child, both during treatment and for at least seven months after treatment is finished. Copegus specific Copehus name of this medication may not be available in all of the Copegsu or approved for all of the conditions discussed here. If you have had a heart attack, heart failure, or changes in heart rhythm arrhythmiasdiscuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Resistance Mechanism Disorders. All rights reserved. Before you take Copegus, tell your healthcare provider if you have or have had:. Stroke: This medication has been associated with stroke. The contents herein are for informational purposes only. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Assess for underlying cardiac disease prior to initiation. Concentration difficulties. You should continue to use contraception to prevent pregnancy for at least four months after your treatment is finished. Didanosine is not recommended for use with this medicine, because the combination may increase the risk of liver problems, pancreatitis, lactic acidosis and peripheral neuropathy. Patients should be monitored closely with periodic clinical and laboratory evaluations. Copegus may cause birth defects. Close more info about Ribavirin Tablets. Breastfeeding should be stopped before treatment with this medicine is started. Use with caution in Decreased kidney function. I accept the Terms and Privacy Policy. The number of patients who received medication in the study was Copegus is manufactured by Roche as a light pink, oval shaped, film-coated tablet containing mg of ribavirin. February 8, Pegasys is currently available at pharmacies. Upon resolution of a laboratory abnormality or clinical adverse reaction, an Copefus in COPEGUS dose to Cpegus original dose may be attempted depending upon the physician's judgment. Nonresponders to interferon. March 24, Physicians and Coepgus are strongly encouraged to report any pregnancies that do occur to Roche by calling The side effects listed above may not include all of the side effects reported by the drug's manufacturer. People with low levels of haemoglobin in their blood anaemia. Treat for 48 weeks Genotype 1, 4 or 24 weeks Genotype 2, 3. Before starting treatment with this medicine you will need to have blood tests to monitor your kidney and liver function, as well as the level of blood cells and haemoglobin in your blood. Related Stories U. Contraindications: Hemoglobinopathies eg, thalassemia, sickle-cell anemia.
Common use

Copegus is used together with an interferon (such as PegIntron or Intron A) to treat chronic hepatitis C which is a disease of the liver. This is a drug for the patients who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body. Copegus belongs to the antivirals.

Dosage and direction

The usual dose of Copegus per day is 800 mg, 1,000 mg, or 1,200 mg i orally in two divided doses (morning and evening) with food for 24 or 48 weeks. The dose and duration of treatment depend on your condition, on body weight, on baseline disease characteristics, response to therapy and tolerability of the regimen. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. It should be taken consistently. For example, it should be taken at the same time or times each day and each time.


Copegus may decrease the number of red blood cells in your body (anemia) and it can be life-threatening in people who have heart disease or circulation problems. Careful consideration is advised if Copegus is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Your blood will need to be tested often. Also your vision, liver function and thyroid function may also need to be tested. Visit your doctor regularly. Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing. Copegus may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take Copegus, and contact your doctor immediately. Women and men who are taking Copegus must avoid pregnancy during treatment with this drug and for 6 months after this medication has been stopped. Consult your doctor or pharmacist for more information.


Before taking Copegus you should talk with your doctor if you are allergic to peginterferon alfa-2a, any other interferon, ribavirin, polyethylene glycol, or to any of the ingredients of the medication, if you are an infant, breast-feeding, pregnant or has a pregnant partner. Also in the way if you have decompensated liver disease, hemoglobinopathies (thalassemia, sickle-cell anemia), HIV-HCV (human immunodeficiency virus and hepatitis C virus) with cirrhosis and a baseline Child-Pugh score greater than or equal to 6. And you should discuss with your doctor if you have a severe psychiatric disorder, autoimmune diseases (including autoimmune hepatitis), thyroid problems not controlled by medication even in the past.

Possible side effects

The most common side effect of Copegus is a flu-like syndrome consisting of body aches and pains, fever, chills, headache and malaise. The most serious side effect is anemia. Patients with certain types of heart disease should not use Copegus. This may make your condition worse and can lead to a possibly fatal heart attack. Copegus should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function. Therapy with Copegus and interferon may aggravate psychiatric conditions or may cause a psychiatric condition such as depression, suicidal ideation, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions. Therapy has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to finish this therapy. Other possible side effects that may occur during therapy with Copegus are fatigue, weakness, nausea, anorexia, heartburn, insomnia, irritability, difficulty breathing, rash, itching, and alterations in taste perception.

Drug interactions

If Copegus is used with other antiviral drugs with similar mechanisms of action it may cause a condition in which lactic acid accumulates in the blood (lactic acidosis). This situation can lead to serious medical problems. Also do not take Copegus with antiviral drugs that used to manage HIV infection (zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit)).

Missed dose

If you miss a dose of Copegus, take the missed dose as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.


Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling. If you experience something from list above you need emergency medical attention.


Store Copegus in the refrigerator, protect them from light, and keep them out of the reach of children. Do not freeze, shake, or use them past the expiry date.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Thyroid problems

Thyroid gland a gland of the organism located in the front part of the neck. The whole gland weights 25-30g. It works by producing 4 hormones amongst which the major are T4 Thyroxin and T3 Tri-iodothyronine. Also the gland produces Calcitonin a biologically active substance that regulates the Ca2+ metabolism in the body.

The thyroid gland, pituitary gland and hypothalamus work as one regulatory system. There are different types of thyroid gland dysfunctions for example:

  • Hypothyroidism A dysfunction which manifests in decreased production or inability to produce thyroid hormones. All the metabolism processes in the organism are slowed down. The causes of the disorder might be autoimmune thyroiditis, therapy with radioactive Iodine, hereditary disorders.
  • Hyperthyroid an excess in production of thyroid hormones. The disorder leads to an increase in the organisms metabolism speed. The causes of the disorder might be: benign tumors, when the gland is not controlled by the pituitary gland, autoimmune processes Graves's disease. The symptoms of the hyperfunction may lead to thyrotoxic crisis or thyroid storm a severe condition which affects the main organism functions and in turn may leading to coma and death.
  • Another dysfunction of the thyroid gland is goiter which is caused by iodine insufficiency, followed by an increase in size of the thyroid gland which may lead to hyper- or hypothyroidism.

If you feel that some of the following may be applied to youthen a possibility of the thyroid disorder exists:

  • Fatigue, especially in the morning and less in the evening
  • Changes in weight, especially around the abdomen
  • Depression and melancholy
  • Increased levels of cholesterol
  • Spasms and muscle contractions
  • Constipation
  • Arthritis and joint pain
  • Bad memory and other neurological

All of the above may signal a possible thyroid disorder. It would be safe to consult your doctor and measure the levels of the T4 and T3 hormones in the blood.